| 2021-07-10 15:00:17July 10, 2021 | Queen of the South v Queen’s Park | 0 - 1 | Premier Sports Cup Group F | 2021-2022 | Palmerston Park |
| 2021-07-14 19:45:15July 14, 2021 | Queen’s Park v Motherwell | 0 - 1 | Premier Sports Cup Group F | 2021-2022 | Wyre Stadium at Firhill |
| 2021-07-17 15:00:17July 17, 2021 | Queen’s Park v Airdrieonians | 0 - 0 | Premier Sports Cup Group F | 2021-2022 | Wyre Stadium at Firhill |
| 2021-07-20 19:45:22July 20, 2021 | Annan Athletic v Queen’s Park | 1 - 2 | Premier Sports Cup Group F | 2021-2022 | Galabank |
| 2021-07-31 15:00:28July 31, 2021 | East Fife v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Bayview Stadium |
| 2021-08-07 15:00:30August 7, 2021 | Queen’s Park v Cove Rangers | 2 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-08-14 15:00:48August 14, 2021 | Queen’s Park v Dumbarton | 3 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-08-21 15:00:59August 21, 2021 | Alloa Athletic v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Indodrill Stadium |
| 2021-08-28 15:00:22August 28, 2021 | Falkirk v Queen’s Park | 0 - 1 | SPFL League 1 | 2021-2022 | Falkirk Stadium |
| 2021-09-11 15:00:17September 11, 2021 | Queen’s Park v Airdrieonians | 0 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-09-18 15:00:27September 18, 2021 | Clyde v Queen’s Park | 2 - 2 | SPFL League 1 | 2021-2022 | Broadwood |
| 2021-09-25 15:00:19September 25, 2021 | Queen’s Park v Peterhead | 3 - 2 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-10-03 15:00:06October 3, 2021 | Queen’s Park v Montrose | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-10-16 15:00:24October 16, 2021 | Dumbarton v Queen’s Park | 0 - 3 | SPFL League 1 | 2021-2022 | C&G Systems Stadium |
| 2021-10-24 15:00:27October 24, 2021 | Queen’s Park v Alloa Athletic | 3 - 4 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-10-30 15:00:06October 30, 2021 | Cove Rangers v Queen’s Park | 3 - 3 | SPFL League 1 | 2021-2022 | Balmoral Stadium |
| 2021-11-06 15:00:38November 6, 2021 | Queen’s Park v East Fife | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-11-13 15:00:26November 13, 2021 | Queen’s Park v Clyde | 0 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-11-20 15:00:09November 20, 2021 | Peterhead v Queen’s Park | 2 - 1 | SPFL League 1 | 2021-2022 | Balmoor Stadium |
| 2021-12-04 15:00:50December 4, 2021 | Queen’s Park v Falkirk | 6 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-12-11 15:00:40December 11, 2021 | Airdrieonians v Queen’s Park | 15:00:40Postponed | SPFL League 1 | 2021-2022 | Excelsior Stadium |
| 2021-12-18 15:00:23December 18, 2021 | Montrose v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Links Park |
| 2021-12-26 15:00:07December 26, 2021 | Queen’s Park v Dumbarton | 15:00:07Postponed | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2021-12-29 19:45:49December 29, 2021 | Airdrieonians v Queen’s Park | 1 - 0 | SPFL League 1 | 2021-2022 | Excelsior Stadium |
| 2022-01-02 15:00:42January 2, 2022 | Clyde v Queen’s Park | 15:00:42Postponed | SPFL League 1 | 2021-2022 | Broadwood |
| 2022-01-08 15:00:26January 8, 2022 | Queen’s Park v Peterhead | 15:00:26Postponed | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-01-15 15:00:09January 15, 2022 | Alloa Athletic v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Indodrill Stadium |
| 2022-01-22 15:00:07January 22, 2022 | Clyde v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Broadwood |
| 2022-01-29 15:00:51January 29, 2022 | Queen’s Park v Airdrieonians | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-02-05 15:00:31February 5, 2022 | Falkirk v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Falkirk Stadium |
| 2022-02-08 19:45:32February 8, 2022 | Queen’s Park v Dumbarton | 2 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-02-12 15:00:03February 12, 2022 | Cove Rangers v Queen’s Park | 0 - 0 | SPFL League 1 | 2021-2022 | Balmoral Stadium |
| 2022-02-19 15:00:56February 19, 2022 | East Fife v Queen’s Park | 1 - 1 | SPFL League 1 | 2021-2022 | Bayview Stadium |
| 2022-02-26 15:00:50February 26, 2022 | Queen’s Park v Montrose | 0 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-03-01 19:45:37March 1, 2022 | Queen’s Park v Peterhead | 2 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-03-05 15:00:18March 5, 2022 | Dumbarton v Queen’s Park | 0 - 3 | SPFL League 1 | 2021-2022 | C&G Systems Stadium |
| 2022-03-12 15:00:06March 12, 2022 | Queen’s Park v Alloa Athletic | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-03-19 15:00:46March 19, 2022 | Airdrieonians v Queen’s Park | 2 - 0 | SPFL League 1 | 2021-2022 | Excelsior Stadium |
| 2022-03-26 15:00:25March 26, 2022 | Queen’s Park v Clyde | 1 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-04-03 15:00:59April 3, 2022 | Queen’s Park v Cove Rangers | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-04-09 15:00:53April 9, 2022 | Queen’s Park v East Fife | 1 - 0 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
| 2022-04-16 15:00:36April 16, 2022 | Peterhead v Queen’s Park | 2 - 1 | SPFL League 1 | 2021-2022 | Balmoor Stadium |
| 2022-04-23 15:00:20April 23, 2022 | Montrose v Queen’s Park | 2 - 1 | SPFL League 1 | 2021-2022 | Links Park |
| 2022-04-30 15:00:04April 30, 2022 | Queen’s Park v Falkirk | 1 - 1 | SPFL League 1 | 2021-2022 | Wyre Stadium at Firhill |
